Volume 9, Issue 2
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Welcome to the First Edition of the IIVS E-newsletter.

Through this online format we plan to update you on recent IIVS activities in Science, Education and Outreach. In addition we will highlight upcoming meetings and other noteworthy news items. We hope you enjoy the new format and welcome your feedback.
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Topical Antioxidants: An In Vitro Model to Assess Their Performance

Currently there is no widely accepted method to evaluate the antioxidant properties of skincare products. IIVS recently undertook a project to develop an in vitro method capable of evaluating the antioxidant potential of antioxidants and antioxidant skincare products in human cells.  NHEKs (normal human epidermal keratinocytes) were subjected to UVA-irradiation to induce oxidative stress and then protection from oxidative stress was evaluated in cells incubated with antioxidants. Cytotoxicity was assessed concurrently using the neutral red uptake assay. Using this method, several known antioxidants and antioxidant-containing formulations were evaluated for their ROS-reducing capabilities.




IIVS is now on Twitter, LinkedIn, and Facebook 

Find IIVS on Twitter, Facebook, and LinkedIn

IIVS is pleased to announce the official launch of our new web site design. Visit us at www.iivs.org to take a look at the following changes and improvements:

  • Step-by-Step general assay procedures with photos in the "Science" section
  •  A breakdown of current training opportunities and highlights of both institute and non-institute sponsored workshops in the "Education" section
  • An explanation of key science-based advocacy programs and partners in the "Outreach" section.

If you were familiar with the previous site, you may have used our "Resources" section to find publications and copies of IIVS newsletters. The search feature is greatly improved in this new site (and powered by Google). Feel free to contact us if you have difficulty finding any materials.

In addition to the improved features, the new website offers several options for keeping in touch with IIVS and getting the latest updates from us. You can click the "RSS feeds" button to be notified whenever we update our news and events postings. You can also follow us on Twitter, connect with us on LinkedIn, and friend us on Facebook to receive updates and interact with us in the forum that works best for you.

Please visit our new website today and send us some feedback or ask any questions that you might have.

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ECVAM's Scientific Advisory Committee (ESAC)

Comprised of 15 experts, including Dr. Rodger Curren of IIVS, the ESAC

is organized to provide ECVAM with independent scientific advice on the validity of alternative test methods. The ESAC, chaired by Dr. David Basketter, met last October to discuss the review of an ECVAM-coordinated prevalidation study of three cell transformation assays (CTAs) for carcinogenicity.


These tests detect phenotypic changes in cells following exposure to test materials. These changes are detected by variations in clonal morphology (Syrian Hamster Embryo cells) or focus formation (Balb/c 3T3 cells). In order to conduct a detailed review of the ECVAM study, a working group of 5 experts was formed including Dr. Curren and Dr. Erwin Roggen (chairperson) who represented ESAC.


The conclusions of the review were reported back to the full committee and will be incorporated into an ECVAM test method recommendation.

News and Upcoming Events
Society of Toxicology Annual Meeting
March 6 - 10   Washington Convention Center
Washington D.C.

 CAAT Evidence Based Toxicology Kick-Off Meeting
March 10   Washington D.C.
Following SOT Annual Meeting

8th World Congress on Alternatives and Animal Use in the Life Sciences
August 21 - 25   Montreal Canada
Call for Papers: Deadline April 10th

IVTIP Spring 2011 Meeting
In conjunction with ESTIV and CAAT
April 26 - 28   Monaco
SOT logo

IIVS Booth #1313

Visit us during the 50th Anniversary SOT Meeting
March 6-9, 2011
Washington Convention Ctr

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HSUS Seeks Nominations for the 2010 Russell and Burch Award  


Deadline for Submission: 

April 10, 2100


Funding For Alternatives 

 Alternative Research and Development Foundation  


Center for Alternatives to Animal Testing  


Hadwen Trust  




American Society for Cellular and Comutational Toxicology 

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 Click here to learn more about ASCCT   



Visit the ASCCT booth at the SOT Meeting:

Booth 971 


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