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A new study led by F.W. Fraunfelder, MD, of the Casey Eye Institute, Oregon Health & Science University, is the first to systematically report on the association of eye disorders with statin use. The study appears in the Dec. 1 issue of Ophthalmology, the journal of the American Academy of Ophthalmology.
Dr. Fraunfelder's group analyzed statin-associated reports of double vision (diplopia), drooping of the upper eyelid (ptosis), and loss of full range of motion of the eyes (ophthalmoplegia) Since statins were known to cause skeletal muscle disorders in some patients, a similar affect was plausible in the eye muscles.
The average statin dose of patients who exhibited one or more eye disorder was within ranges recommended by drug manufacturers, and the average time from beginning of therapy to developing an adverse drug reaction (ADR) was 8.3 months. There were 23 cases of loss of eye range of motion, 8 cases of ptosis, and 18 cases of ptosis in conjunction with double vision; disorders in all patients apparently resolved completely when statins were discontinued.
"We advise physicians prescribing statins to be aware that these eye disorders may result, and that medications should be discontinued if so. When a patient has one of these eye disorders, he should be rigorously evaluated to determine the cause, and statin use should be taken into account," Dr. Fraunfelder concludes.
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