University of Michigan Life Sciences Institute


August 11, 2010
In This Issue
LSI Scientist Named 2010 Pew Scholar: Bing Ye
Dive Journal: LSI's David Sherman Documents His Work on Land and Sea
Deadly Virus' Crystal Structure Solved: Janet Smith's Lab
The Latest LSI News and Research


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Got Team? Creating Championship Science
by Alan Saltiel, LSI Director

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OK, I admit it. I'm a sports junkie. The first thing I do in the morning is read the sports section in the paper, and once or twice a day I glance at ESPN.com to check out the latest scores and rumors. I rarely miss a game of my favorite college basketball team. While working at home I have a game on the TV as background, and I'm a sucker for almost any sports movie. Worst of all, I constantly use sports clichés and metaphors (often mixed) to weigh in on almost everything.  

 

The thing is, many of the principles that guide me in science were learned in sports. Besides the obvious things like hard work, consistency, awareness, preparation, opportunism, persistence, etc, the one precept that really sticks out is the central role of teamwork. While this is a given in sports, it is not a central tenet of scientific discovery.

 

It should be. The results brought by teamwork are indisputable, as is the excitement and personal fulfillment. But how do you get scientists to work together? I have pondered this question often during my ten years in industry and sixteen years in academia as a leader and member of different kinds of scientific organizations. Deep discussions I've had with leaders in industry and academia, and not just in the life sciences, always come back to the same dilemma, the tension between the "I" and the "We", and the likelihood of tipping too far to one side or the other. I've concluded that creating a culture of innovative discovery depends critically on achieving the right balance, and developing a value system where this tension is minimized, so that the "I" exists in harmony with the "We".


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Bing Ye Named a Pew Scholar
Second Year in a Row for LSI Scientists

Bing Ye, Life Sciences Institute (LSI) research assistant professor and assistant professor of cell and developmental biology at the Medical School has been named a Pew Scholar.


LSI faculty Bing Ye in his lab
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The Pew Charitable Trusts named
Ye, along with 20 other outstanding scientists from across the country as the 2010 Pew Scholars in the biomedical sciences. Early to mid-career scientists compete to be chosen by the program each year. Pew Scholars receive a $240,000 award over four years to support and expand his or her research as well as foster collaboration and connection through thought exchanges with other stellar scientists.

 

"Bing Ye's exuberance and dedication show in his work-he is one of the LSI's brightest young scientists. I'm not surprised that he now can add Pew Scholar to his list of accomplishments-and contributions to the field," says Alan Saltiel, LSI director.


Read the full story.

Part One: Read David Sherman's
Dive Journal

Peek into the pages of his Costa Rica
expedition notes

David Sherman in the Costa Rican jungle
Sherman























LSI scientist and explorer David Sherman recently returned from an expedition to Costa Rica in support of his multi-year drug discovery and bioenergy project. Though he faced rough seas, wild boars, and howling monkeys, he and his team made it through safely and back to the lab with hundreds of samples hand-plucked from the sea floor and decaying jungle logs.

Read part one of his story and see photos from his dives and sample collection in the remote seas and jungles of Costa Rica
Janet Smith's Lab Solves Crystal Structure
Recently published: Mystery of the Rift Valley Fever virus protein family unlocked

PNAS Smith












LSI research professor Janet Smith and colleagues have solved the structure of the nucleocapsid protein from Rift Valley fever virus (RVFV), so named for the region of sub-Saharan Africa where it was first isolated with outbreaks reported throughout the African continent as well as the Middle East.

 

RVFV infects livestock and humans and is most often transmitted by mosquitoes, usually after periods of heavy rain. The virus is also spread through the handling or consumption of infected meat. Effects of RVFV infection in humans are flu-like symptoms, encephalitis, hemorrhagic fever, and/or death in 1% of cases. Livestock deaths from RVFV infection are much greater.

 

Their findings were published in PNAS.


Read the full story.

What's new on the LSI Website
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About University of Michigan Life Sciences Institute


At the University of Michigan Life Sciences Institute (LSI) a team of more than 400 professionals-including world-class faculty and researchers in chemistry, cell and developmental biology, physiology, human genetics, bioinformatics, hematology and oncology works together to solve fundamental problems in human health. Founded in 2002, the LSI serves as an intellectual and biomedical technology hub for the entire University of Michigan system.  

 
University of Michigan Life Sciences Institute
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