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Alternative Medicine in the News October 2009 edition 42 published weekly
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Warning: Epilepsy Drug Harms Babies' IQ
Pregnant women who take a widely prescribed epilepsy drug give birth to
children with lower average IQs, according to a study conducted by
researchers from Emory University School of Medicine and published in
the New England Journal of Medicine.
Researchers
conducted IQ tests on 258 children between the ages of two and three,
all of whose mothers had been prescribed antiseizure medication from
one of 25 epilepsy centers in the United States or United Kingdom
between October 1999 and February 2004. A total of 53 children in the
study had been born to mothers who had taken the best-selling drug
valproate, marketed as Convulex, Depakene, Depakine, Epival or Stavzor.
Valproate is the second most popular antiseizure drug used to treat epilepsy. Prior research has linked its use by pregnant women to birth defects and slowed infant development.
Researchers found that the average IQ
of children who had been exposed to valproate in utero was 92,
significantly lower than the average of 100. In comparison, the average
IQs of children prenatally exposed to the drugs carbamazepine,
lamotrigine and phenytoin were all within two points of 100.
The researchers said that doctors should never prescribe valproate as a first choice to epileptic women of childbearing age.
"My thought is that if I make a mistake and the patient has a breakthrough seizure, I can change the medication
and switch the patient to valproate," lead author Kimford J. Meador
said. "If I put the patient on valproate as a first choice and the baby
has cognitive impairment or a malformation, I can't repair that."
Epileptic women give birth to between 13,000 and 21,000 children each year.
Women
currently taking valproate should not discontinue the drug without
consulting a physician first, warned Eric Hargis of the Epilepsy
Foundation.
Valproate is also used to treat bipolar disorder, depression, migraine and schizophrenia.
Sources for this story include: www.nytimes.com.
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Infant Hepatitis B Vaccine Triples Risk of Autism in Boys, Study Says
While the mainstream media is touting the latest study showing that the
Hepatitis B vaccine they routinely hit newborns with (literally, in the
birthing room) reduces liver cancer, they are ignoring a new study
published (as an abstract) in the September issue of Annals of Epidemiology.1
That
study, conducted by Carolyn Gallagher and Melody Goodman of the
Graduate Program in Public Health at Stony Brook University Medical
Center, New York, found that newborn boys who received the Hepatitis B
vaccine had a higher chance of getting ASD (autism spectrum disorder). On the order of 2.94 times higher.
The study, published in abstract in the Annals of Epidemiology, is awaiting full publication in a peer-reviewed journal. The study is under review.
The
study surveyed infant boys who received a Hepatitis B vaccine within
one month of birth and compared them to another survey of
non-vaccinated boys. The results were compared to overall information
found using probability samples from the National Health Interview
Survey (NHIS) from 1997-2002 data sets (the latest available).
The conclusion?
"Findings suggest that U.S. male neonates vaccinated with hepatitis B vaccine had a 3-fold greater risk of ASD; risk was greatest for non-white boys."
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Study: More cases of autism in U.S. kids than previously realized
www.CNN.com
[comment from Didi: Autism -a disease that did not exist 50 years ago- is on the rise in Kenya, too. Unfortunately this article makes no mention of the connection between drugs or vaccinations and the rise of autism. The mass media remains deathly silent on this growing evidence. They write about Autism and all other diseases as if there were no connections at all to the increasing invasion of drugs into our lives.]
A study published Monday in the journal Pediatrics indicates about 1
percent of children ages 3 to 17 have autism or a related disorder, an
increase over previous estimates.
"This is a significant issue that needs immediate attention," Dr.
Ileana Arias, deputy director of the Centers for Disease Control and
Prevention said Friday. "A concerted effort and substantial national
response is warranted."
The study used data from the federal
government's 2007 national survey of children's health. The survey of
parents was conducted by the Health Resources and Services
Administration, and by the Centers for Disease Control and Prevention.
The results are based on a national telephone survey of more than 78,000 parents of children ages 3 to 17.
In the study, parents were asked whether a health care provider had
ever told them their child had an autism spectrum disorder. ASD is a
group of brain disorders comprising autism and two less severe disorders: Asperger's disorder and pervasive developmental disorder not otherwise specified.
Children with the disorder show impairment in social interaction and in
their ability to communicate. They often display repetitive behavior.
The investigators also asked a follow-up question: Were the children
considered to have ASD now? Nearly 40 percent of the parents and
guardians said no.
That finding led the authors to question
whether some of the children originally diagnosed as having ASD may
have been improperly diagnosed, since the disorders are not considered
curable.
But Kogan said the two surveys cannot be compared
because the earlier investigators did not ask the follow-up question
about whether the children were still considered to have the disorder.
Still, based on the findings, lead author Dr. Michael D. Kogan of
HRSA's maternal and child health bureau estimated the prevalence of ASD
among U.S. children ages 3 to 17 at 110 per 10,000 -- slightly more
than 1 percent.
Boys were four times as likely as girls to have
ASD, and non-Hispanic black and multiracial children were less likely
than non-Hispanic white children.
He estimated that 673,000 children have ASD in the United States.
Monday's findings of nearly 1 in 100 appear to indicate an increase
from the average of 1 in 150 that was reported in 2003, the researchers
said.
The researchers urged caution in interpreting the change, noting that
an increase in diagnoses does not necessarily mean that more children
have the disorder. It could simply reflect a heightened awareness of
the disorder.
"We don't know whether the change in the number
over time is a result of the change in the actual condition, in the
actual number of conditions or in part due to the fact that the
condition is being recognized differently," Arias said.
She said
that preliminary results from a separate, CDC-funded study she is
working on also indicate that about 1 percent of children in the United
States are affected by ASD. That study is to be published later this
year, she said. |
Placebo Effect Regularly Beats Pharmaceutical Drugs
A Wired UK article just told us a dirty little secret that the
pharmaceutical drug world would rather keep quiet. That fact is: drugs
are having a difficult time beating the placebo effect, and
increasingly so. In fact, they're finding the placebo effect is getting
stronger in people, making it more difficult for drugs to show any
improvement over it. The credit for the increased placebo effect has
been attributed to the increase in consumer advertising, which makes
many consumers "believe" more in the drugs and their effects.
Because the placebo effect
is getting stronger, many widely distributed drugs would have had a
hard time getting approval to begin with, if they were tested against
today's placebo effect. Many drugs, notably Prozac, have also been shown to falter when compared to placebo - after they're already on the market.
A Saatchi & Saatchi advertising
executive explains the key to producing a good pharmaceutical ad: it's
in making the association between the drug and other aspects of life
that promote peace of mind, like playing with your kids or reading a
good book.
It's Madison Avenue type stuff, designed to play on
your emotions and specifically, to boost sales. These messages appear
to be working because many people keep calling on doctors for more
drugs, which is the drug company's number one goal. But, interestingly,
the same mechanism also seems to be messing up the new drug approval
process for drug companies.
Wired tells us, "The fact that an increasing number of medications are unable to beat sugar
pills has thrown the industry into crisis" and that "half of all drugs
that fail in late-stage trials drop out because of their inability to
beat sugar pills." Eli Lilly's next-generation antidepressants
haven't been doing better than a placebo in seven out of ten trials. It
wasn't long ago that Merck withdrew its "highly anticipated medical
breakthrough" antidepressant for the same reason; it didn't beat sugar
pills.
It's interesting because placebo pills are often sugar pills, and sugar is known to depress the immune system for hours after it's taken. So, in truth, drug companies are having a difficult time competing against an immune system depressant.
William Potter, psychiatrist turned Eli Lilly
drug developer, found himself baffled by the evidence that drugs he'd
long been prescribing were now failing against placebos. So, he started
digging around in Eli Lilly's trial database, a database that included
trials the company didn't make public and preferred to keep quiet.
Inside
that database, Potter found there were tremendous differences in the
results of drug trials, based on things like the size and color of the
pills, and even where in the world the trial was located.
For
example, blue tranquilizer pills have better effects than red pills,
even with the same stuff inside. This is the case in all but Italian
men, which with whom the color blue is associated with their national
football team. And Valium often beats the placebo in France and
Belgium, but regularly fails in the U.S.
Other research has
found that patients do better with a caring doctor who takes time with
them, compared to a non-caring doctor who doesn't bother with
communication, even if they are both given the same placebo.
These
random factors can sway drug trials one way or the other, yet drug
companies aren't required to submit for regulatory review all of the
tests they run on a particular drug. They can submit just the ones they
do well in and keep the ones that they fail to themselves, even if the
factors for "doing well" are as esoteric (and non-scientific) as the
color of the pill given, the branding of the pill, the price of the
pill, or which country the trial was held.
Fabrizio Benedetti studied the placebo effect on his own, because funding couldn't be found to study something the drug industry considers to be getting in the way of profits.
Building
on previous research, Benedetti found that when someone is given a
pill, the brain expects change to happen. Based on that expectation,
the brain often then starts producing its own pain-relieving medicine,
which can reduce pain and even regulate heart and respiratory
functionality.
Instead of working to understand how the body can
heal itself, drug companies see this, the placebo effect, as a
nuisance. In fact, these days, daily doses of immune-depressing sugar
pills might cause bigger problems for drug companies than their direct
competitors do.
It'd be curious to see what would happen if the
sugar pills were replaced with a whole foods diet, or supplementation
with placebo herbs like cat's claw, garlic, or other known immune
system enhancers. Perhaps, this should become the standard for the
testing of pharmaceutical drugs, as testing against substances that are
known to depress the immune system isn't really a level playing field,
even if the drug companies are routinely failing.
Of course, if
this were to happen, far fewer drugs would pass the already flimsy
approval requirements that allow for the cherry picking of data and
hiding of negative results. And this isn't something the drug industry
wants.
More: http://www.wired.co.uk/wired-magazi... http://www.naturalnews.com/001810_a... http://www.healingdaily.com/detoxif...
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Diabetes Drug Could Cause Pancreatic Cancer
The popular diabetes drug sitagliptin (marketed as Januvia) may
increase the risk of pancreatic cancer, according to study conducted by
researchers from the University of California-Los Angeles and published
in the journal Diabetes.
"Type 2 diabetes is a lifelong
disease -- people often take the same drugs for many years, so any
adverse effect that could over time increase the risk for pancreatic
cancer would be a concern," said lead researcher Peter Butler. "A
concern here is that the unwanted effects of this drug on the pancreas would likely not be detected in humans unless the pancreas was removed and examined."
Previous research has suggested that the diabetes drug Byetta might increase the risk of pancreatic inflammation (pancreatitis), a known risk factor for pancreatic cancer.
Byetta and Januvia both act by enhancing the activity of a gut hormone
known as glucagon-like-peptide-1 (GLP-1), thereby resulting in lower blood sugar.
Byetta
manufacturer Amylin Corp. has insisted that the connection between
Byetta and pancreatitis could be coincidence, since no mechanism to
explain the correlation has yet been found. The new study suggests,
however, that enhanced GLP-1 activity might itself be a risk factor for
pancreatitis.
Researchers conducted the study on rats that had been genetically engineered to simulate the metabolism of humans with Type 2 diabetes,
as well as their Islets of Langerhans. They treated 40 rats with either
Januvia or a Januvia-metformin combination for 12 weeks.
The Islets of Langerhans are hormone-producing regions of the pancreas. Metformin is an older diabetes drug that is believed to have tumor-suppressing properties.
The
researchers found that rats treated only with Januvia had significantly
higher proliferation of beta cells in their Islets of Langerhans, while
some developed pancreatic abnormalities or inflammation. Rats treated
with both drugs did not exhibit this effect.
Beta cells produce the blood sugar-regulating hormone insulin.
Sources for this story include: www.upi.com; www.sciencecentric.com.
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Olive Oil Provides a Cure for Over Sixty Diseases
The olive, or zaitoon in Arabic, is a sign of friendship and peace and
it is a cure for over 60 diseases. According to religious beliefs,
after the flood of Noah, the first plant seen was the olive tree. The
olives, the olive oil and especially the olive leaves are full of
nutrients, vitamins and healing. They contain anti-bacterial,
anti-inflammatory, anti-fungal, anti-viral properties and many vitamins
and nutrients.
The olive leaf itself is known for the treatment
and curing of many diseases, including the much feared influenza virus.
Olive leaf is good for fighting yeast infections,
flu and virus, treating those with cardiovascular problems and lowering
cholesterol. Even the twigs of the olive tree are used to clean the
teeth with. This twig is called miswak in Arabic and it has many health benefits also.
The
olive tree is found in Asia, Palestine, Greece, Portugal, Spain,
Turkey, Italy, North Africa, Algeria, Tunisia, California, Mexico,
Peru, and parts of Australia. The olives
are pickled and not eaten fresh from the tree. After picking the
olives, you must remove the seeds and split them open. Then you soak
them in salt for several days. After they are cured to lose their sour taste,they are then pickled in a water solution with lemon and hot chilies. Olives are a delicacy in all Arab countries.
The olive oil
is used as a preservative on many foods such as tomato sauce, hot
pepper sauces, fish, and many vegetables, such as stuffed eggplant. A
favorite of many is the yogurt balls in olive oil. Olive oil is part of
the Arab diet and used in many ways. Many Arabs have olive oil every
morning for breakfast with humus, yogurt and dips. It is not only
delicious, but extremely healthy.
Natural Health Remedies: The
olive oil will alleviate muscle pains. You can warm the olive oil
slightly and rub it on the pain. It is also a treatment for
hemorrhoids, leprosy, pleurisy, skin diseases, dandruff, eczema,
psoriasis, alopecia and fungal infections including ringworm, and it
increases sexual desire.
Olive oil is great for the complexion
as it makes it glow. When it is mixed with salt, the mixture can be
used as a remedy for gum and teeth problems. Olive oil provides
protection from poisons, helps in the digestions process, expels worms
and makes the hair shiny and beautiful. Olive oil is also great for
anti-aging and longevity.
Olive oil is a good treatment on boils,
rashes, itching, mouth ulcers, allergic dermatitis, scars, boils and
small pox. The olives them self, are used to rid the body of constipation
and the leaves are smashed to rid excess perspiration. Ear aliments are
alleviated by using the juice of the leaves mixed with honey. Olive oil
used in the eyes will relieve inflammation.
Some
doctors also recommend olive oil for the treatment of epilepsy. Olive
oil is a good diuretic and therefore very good for the ridding of
kidney stones. Olive oil will heal sinus problems and if mixed with
barley water will rid the body of constipation.
It is stated,
but not proven, that olive oil rids the body of gall bladder stones. It
is good for intestinal inflammations and distress. Olive oil is also
good for excess acidity and gas. It has been noted that people who take
regular amounts of olive oil do not suffer from colds and the flu as
much.
Buying cold pressed olive oil is not a simple matter.
There are numerous grades of olive oils. It can be as difficult as
choosing a fine wine. Many companies sell many oils, but choosing the
right one at the right price is the task. Always look for a deep rich
green color and it must be cold pressed. To cook with olive oil, you
need to have virgin olive oil not extra virgin olive oil.
Virgin
olive oil is pressed twice, but still needs to be cold pressed. The
grades of oils depend on the country and the type of tree. All oils
should be kept in a dark cool place and kept out of the sunlight. Olive
oil remains good for six months after opening the bottle or can.
http://greekfood.about.com/od/greek... http://www.missionislam.com/health/... http://en.wikipedia.org/wiki/Olive_oil
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Get the Right Dose to Correct Vitamin B12 Deficiency
Vitamin B12 deficiency is a common problem that is often overlooked, but once a doctor FINDS vitamin B 12 deficiency in a patient, it's likely that the person will STILL suffer from their symptoms even AFTER
treatment because most doctors, historically, give too low of a dose to
correct the symptoms that occur in vitamin B12 deficiency.
There
are many pitfalls along the road to getting a diagnosis of vitamin B12
deficiency and the vast majority of those suffering from this problem
get overlooked by western medicine. But when someone actually GETS a diagnosis, the patient is STILL
likely to not benefit from supplementation because the clinician will
most often not give enough of the vitamin to make a difference in how
the patient feels. When a patient has vitamin B12
deficiency, doctors most often give a 'standard' dose of 1000
micrograms per day for treatment. While some people will respond to
this dose and feel better, researchers believe that this dose may be WAY too low in a large subset of patients who need much higher doses in order to feel better.
"The lowest dose of oral cyanocobalamin [a form of vitamin B12] required to normalize mild vitamin B12 deficiency is more than 200 times greater than the recommended dietary allowance" 'Cyanocobalamin Supplementation in Older People With Vitamin B12 Deficiency'
It's rare that studies on vitamin B12 actually look at the SUBJECTIVE feelings of a patient in order to determine need for therapy; most rely on OBJECTIVE markers such as blood
levels, but it seems that the more reliable and effective determination
of the need for vitamin B12 therapy is sense of well-being. One study
took people complaining of fatigue who had NORMAL vitamin B12
levels and gave them increasingly higher doses of vitamin B12 until
they simply felt better. They then repeated the vitamin B12 levels and
found that the patients with the highest vitamin B12 levels scored the
best on a mental and emotional questionnaire. There are Almost No doctors who continue to INCREASE
the dose of a therapy based on a patient's feelings of well-being when
blood tests show normal levels, but other studies also confirm that
this may be EXACTLY the way vitamin B12 deficiency SHOULD be treated.
In
fact, some studies showed that it required up to 9000 micrograms per
day (9mg) in order to achieve the 'maximum feeling of well-being' as
reported by patients REGARDLESS of their vitamin B12 level!
That's 9 times higher than the standard dose that doctors give in order
to correct deficiency. But that seemingly 'megadose' of 9000 micrograms
per day was used specifically for the treatment of fatigue; vitamin B12
has been used in doses up to 40 milligrams per day, that's 40,000
micrograms per day, in order to treat or to delay progression of
nervous system disorders such as Alzheimer's Disease and Multiple
Sclerosis. The vast majority of these studies ALSO showed that
almost no one had any ill effects from such high doses, so it's
undeniable that this vitamin is safe in doses much higher than the
'standard' 1000 micrograms per day.
Doctors, however, generally want to find the lowest
dose that corrects the deficiency as determined by blood levels. In the
case of vitamin B12 deficiency, since extremely high doses have been
repeatedly shown to be safe, correcting DEFICIENCY should not be the ultimate goal, but correcting the SYMPTOMS
that brought the patient into the doctor's office to begin with should
be. Unfortunately, individualizing care and giving different doses to
individual patients who may need more than the standard dose is not
what occurs in actual practice the majority of time. This leaves tens
of thousands across the nation still suffering from fatigue because the
'standard practice' in vitamin B12 deficiency is to look at laboratory
testing and not the most important part of the equation- whether a
patient actually feels better.
Resources: 1)http://archinte.ama-assn.org/cgi/co... 2)http://www.thorne.com/media/chronic... 3)http://www.ncbi.nlm.nih.gov/pubmed/... |
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Medical Disclaimer:
The information contained within does not take the place of medical diagnosis or
prescription. See your health care provider in case of sickness.
Editorial Disclaimer: Publication of these articles are to promote food for thought. The opinions expressed in these articles may not be the opinion of editors.
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