Alzheimer's disease is a devastating neurological
condition that slowly but inexorably destroys the ability
to think, eventually robbing a person of both his
memory and ability to function independently.
First described by Dr. Alois Alzheimer a century ago,
Alzheimer's disease now affects more than 15 million
people worldwide. With the rapid aging of society (an
estimated 30% of the US population will be 65 or older
by 2050), upwards of 14 million Americans are
projected to develop Alzheimer's in the coming
decades.
While medical researchers have yet to pinpoint a
single cause of Alzheimer's disease, they have
uncovered some of the basic biochemical processes
that underlie the hallmark mental changes seen in
Alzheimer's.
Alzheimer's delivers a crushing blow not only to the
affected individual, but also to family members, who
frequently struggle to provide the ever-growing levels
of care required by the patient.
First, Alzheimer's sufferers exhibit a marked decline in
levels of acetylcholine, a neurotransmitter (that is, a
chemical messenger of the nervous system) that is
vitally important to memory formation and retention in
certain regions of the brain. Second, Alzheimer's
patients demonstrate an accumulation of harmful beta
amyloid deposits, or senile plaques, in the brain.
Third, brain autopsies of Alzheimer's patients show
signs of significant oxidative damage induced by free
radicals. Finally, new research indicates that
advanced glycation end products may also initiate this
dreaded condition.
Neurofibrillary tangles, which are made of a protein
called tau, are bundles of twisted filaments found
within neurons. Tau is normally responsible for
helping cells to function correctly; it delivers various
substances throughout the cell. In people who have
Alzheimers disease, tau becomes abnormally shaped
and twists into pairs of helical filaments that gather in
tangles. Because of the tangles, the neurons lose their
ability to function, and the neurons eventually die. No
one knows why this happens but there are probably
several overlapping causes of Alzheimers disease.
There are many choices of both drugs and nutritional
supplements available for patients with Alzheimer's
disease. In light of new evidence that oxidative stress
and inflammation are central to Alzheimers disease,
people at risk of Alzheimers (or those who have early
dementia) are advised to take supplements that
reduce inflammation and oxidative damage.
The following are options that can be used in an Age
Management Medicine program for the prevention
and treatment of Alzheimer's disease.
Although these supplements are available over the
counter, it is best to work closely with an experienced
Age Management Medicine physician who can
determine the best plan and dosage of each
one.
Curcumin
EPA/DHA
Vitamin E
Vitamin C
Ginkgo biloba
Acetyl-L-carnitine arginate
CoQ10
N-acetylcysteine
Aged garlic
Vinpocetine
Green tea extract (93 percent polyphenols)
B vitaminsA full complement of B vitamins (including
folate, vitamin B6, and vitamin B12) to lower
homocysteine
Niacin
Niacinamide
Melatonin
DHEA
Huperzine
Blueberry extract or Blueberries
Grape seed extract