Although the causes of Alzheimer's disease are not completely understood, amyloid-beta (A-beta) is widely considered a likely culprit - the "sticky" protein clumps into plaques thought to harm brain cells.

But now researchers at Washington University School of Medicine in St. Louis have uncovered evidence strengthening the case for another potential cause of Alzheimer's. The finding also represents the first time scientists have found a connection between early- and late-onset Alzheimer's. In a study published in the Oct. 4, 2007 issue of the journal Neuron, the scientists report that when A-beta is made, a small bit of protein is also released that can regulate cholesterol levels in the brain. The discovery adds weight to the less prominent theory that abnormal brain cholesterol metabolism plays a role in the mental decline seen in Alzheimer's patients.

A new US study on mice suggests that a diet rich in carbohydrates with a high glycemic index (GI) not only expands waistlines but may also lead to fatty liver, a condition that results in liver failure and death. The study is published in the September issue of the journal Obesity and is the work of Dr David Ludwig, director of the Optimal Weight for Life program at Children's Hospital Boston, and colleagues. Fatty liver is increasing in line with rising rates of obesity among Americans. The researchers hope to confirm their findings in a newly launched clinical trial with overweight children and to show that the trend can be reversed through changes in diet.

Inflamm-aging: Inflammation as a cause of Aging Silent inflammation is the root cause for many, if not most, of the chronic diseases of aging. Acute inflammation is the body's response to injury, illness, infection, and stress.

Research shows that excessive inflammation lingers below the surface, its chronic form becoming a silent killer. Silent inflammation exists below the threshold of perceived pain, and can smolder silently for decades. We now know that silent inflammation damages arteries; destabilizes cholesterol deposits; destroys nerve cells in the brain; depresses the immune system; promotes formation of cancers; and can activate harmful genes. This silent killer can be traced as the root cause of the diseases of aging, from heart attack, cancer and diabetes to kidney failure and pancreatitis.

Researchers have made a groundbreaking discovery into the prevention of Alzheimer's disease, after showing that boosting testosterone levels in the body can lower levels of a toxic brain protein linked to the development of the crippling condition.

Preliminary results from a clinical trial of West Australian men, presented at the prestigious Royal Society of Medicine in London, show that not only does the use of a testosterone cream lower the protein beta amyloid but importantly it appears to improve memory. Professor Ralph Martins, of the Sir James McCusker Foundation for Alzheimer's Research at Hollywood Private Hospital, said from London that he was excited by early results from an ongoing trial of healthy men aged 50 to 72 who had a testosterone deficiency and only mild signs of memory loss. They have been treated at Perth's Well Men Centre using a WA-made testosterone cream, and the trial follows an earlier study of guinea pigs which showed the treatment reduced their levels of beta amyloid. Professor Martins said that it was the first real evidence of cause and effect. "In the past we've shown an association, so when you lower testosterone, you raise beta amyloid levels, and we've also shown an association with people at higher risk of getting Alzheimer's, but we wanted to see what happens in the brain," he said.

BIOMARKERS OF AGING: the variables that play the largest role in determining your health and vitality for a lifetime.Biomarkers are objectively measured variables which help in the assessment of determining your biological age -your body's actual age as opposed to chronological age- the number of birthday's you have had.

BIOMARKERS OF AGING can be improved throughout your lifetime giving you a younger Biological Age even though your Chronological Age may be higher. The GOAL of a program in Age Management Medicine is to lower your Biological Age by changes in Nutrition, Exercise, Supplementation and Hormone Balancing and Replacement. All of these factors contribute to your Biological Age and can be optimized to improve your overall body function so that your Biological Age is 8-20 years younger.

This book will cover the exciting program which Dr. Casas offers to her patients, including the Exercise Prescription by Lee Haney, and the most up-to-date information in Age Management Medicine/Preventive Medicine.

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