Marijuana (cannabis) appears to have originated from Central Asia and was being consumed long before man was writing things down. Archeological discoveries indicated that it had been known to be in China since at least 4000 BC! It was described by the Emperor of China, Shen Nung (he discovered tea also) for its properties and therapeutic uses in a compendium he wrote in 2737 BC. In 1839, a British physician William O'Shaughnessy discovered it in India and described its therapeutic uses for nausea, muscle relaxation,seizure control and pain relief. In 1854, cannabis was listed in the US Dispensatory and was sold freely in pharmacies of western countries. It was available as a tincture and extract in Britain for over 100 years.
It was in 1937 that the American authorities condemned cannabis for
being responsible for insanity, moral and intellectual deterioration,
violence and various crimes- apparently setting the stage for making it
illegal and to tax it. Also in 1937 (following the lifting of alcohol prohibition) the US Government introduced the Marijuana Tax Act: a tax of $1 per ounce when used for medical uses and $100 an ounce for unapproved uses. It appears there is precedence for how we can potentially tax this product if we go back to this legislation for review. Remember, we were in a depression in the 30's (paralleling the current severe recession) so perhaps we were looking for new tax revenue (like now)? In 1942, cannabis was removed from the US Pharmacopoeia, thus losing its therapeutic legitimacy.
As stated in my introductory paragraph of this newsletter, there recently is all this talk of medically indicated marijuana. In 1978, following a lawsuit filed by a glaucoma patient who was treating himself (apparently not even physician recommended), the government created a compassionate program for marijuana cigarrettes. Twenty people were allowed to legally have marijuana cigarettes under the supervision of the National Institute on Drug Abuse following approval by the FDA for this stated program. The program was discontinued in 1991 by President Bush but in 2004 there were still 7 individuals registered and receiving government regulated marijuana. The government does have a standardized marijuana approved, allowing a few growers to provide a regulated product for ongoing medical research to look into is potential uses for disease treatment/management. The government regulates the potency and species to be used for research in order to provide consistency and a standard. There are a wide range of cannabis species with various potencies and characteristics (hence the market for marijuana).
Cannabis has over 460 known chemicals, 60 of which are under the name cannabinoids. THC is the major psychoactive ingredient. There is now a well recognized receptor system in the body for the cannabinoid chemicals. Our body makes at least 2 chemicals which stimulate these receptors and have effects on neurotransmission and appetite stimulation. The compounds in marijuana also stimulate these receptors and are responsible for the various effects that using this drug has on people. The medical field hopes to have medication that takes advantage of the endocannabinoid system to decrease appetite and help with weight loss. Officially there are no US Food and Drug Administration approved indications for smoking marijuana.
There are 14 states
that have decided to override the federal
position on smoking marijuana for medical treatment. California was the
first in 1996 and is the only one that has legalized dispensaries. The American Medical Association
has weighed in on this issue as well. It is considered a schedule one substance (highest risk for abuse for which no beneficial purpose has been meaningfully proven). The American College of Physicians
are on record as recommending this schedule classification be revisited and revised- mainly in order to lower the legal risk for physicians to recommend it and also to lower the barriers to promote more research into it's potential therapeutic benefits. The ACP
also states that the data suggest it has less dependency potential than other drugs.
On a more harmful note, there are health hazards from the smoking delivery system and to date no adequate data regarding health benefits from smoking marijuana. There is now a vaporizing device called the Volcano vaporizer that will liberate the chemicals of marijuana without creating smoke. This device doesn't come out and say it is for marijuana but rather it is for herbal distillate use. There are recipes for getting various herbal flavors from various plants/herbs. This sleek looking metal flask heats the plant to near burning and the volatile chemicals rise into a collection bag which has a mouth piece/opening to release the collected contents. A person can inhale the contents of the bag to receive delivery of the drug to the mucosa and lungs without the smoke. Vaporization could be a method of delivery that merits further study. See the comments about Sativex
two paragraphs below.
There are two medically approved medications that contain cannabinoid chemicals. One is a synthetic THC patented as Marinol
(approved in the US in 1985) for chemotherapy related nausea in cancer patients and HIV related weight loss/anorexia. I have
and my experience with patients using it is
similar to the data- it helps but has significant side effects. There
are other available products that work better and are better tolerated.
You can get high from Marinol
which limits its
tolerance, especially in the elderly. Another FDA approved medication is an analog (similar but not exactly) of THC and is patented under the name Cesamet
. Its indication is also chemotherapy related nausea in cancer patients. This product has been available in Canada since 1982.
In the interest of brevity I would like to summarize some other conditions
that have been touted as being medical benefited from marijuana. The diseases that have been reasonably studied to date and do show some benefit in terms of having effects over placebo include: 1) mild to moderate pain relief (minimal and conflicting data) 2) antispasmodic and muscle relaxant properties for certain symptoms in multiple sclerosis and spinal cord injuries, 3) promising data on Tourette's syndrome for reducing vocal and motor tics as well as behavioral and obsessive-compulsive features seen in this syndrome, 4) marginal data for epilepsy.
There is increasing interest in possible anti-inflammatory and immunologic effects (especially on cancer cells). The low down on glaucoma is that the drug does lower eye pressure but only for a few hours with each dose and at the cost of significant side effects. There are many other far better products currently available for this condition. The most recently promising cannabinoid medication that is presently approved in Britain and some European countries and is being studied for approval in the US comes under the brand name Sativex
. This is an aerosolized inhaled form of THC and a second ingredient known as CBD. It does help with cancer related pain and due to the CBD component is better tolerated and more effective for pain relief. It is produced by GW pharmaceuticals (British company). Most recently an article described at a basic science level new data that even Alzheimer's pathology might be benefited from the compounds in marijuana. Can we imagine the market for this if we find a useful way to target this disease?
I would like to summarize my conclusions of researching this rather broad topic. Marijuana has been around for a long time and has been used medically centuries before our country was formed. The US and other western nations did use it medicinally up until the 1930's/40's. It was politicized and even taxed in our prior history as a nation and now it appears on the same path. There are no FDA approved indications for the smoking of marijuana and
due to the health hazards of this delivery method most physicians would
agree with the FDA's position. Recreational
and commercial marijuana is a topic of debate but I am bothered that
the media and perhaps the public at large is accepting this idea that
there actually are approved indications for smoking marijuana-there are
. Articles that lead people to believe that there are accepted
indications for medical marijuana are starting with a false/untrue
premise and I simply want folks to know this.
It is my opinion that the people advocating marijuana for medical indications really are interested in legalizing it for recreational and commercial reasons. The black market marijuana
has been bred for the euphoric potency of the THC component of the
marijuana plants and thus some of the medically helpful substances being
studied might not actually be in the "street versions" of marijuana.The medical profession has been used as an "in" for legalizing the smoking of this recreational drug. There are currently proven areas for which cannabis derived medications are approved and prescribed. More study into marijuana might lead to other indications as well as better delivery systems and "mixes" that might offer better safety, tolerability, as well as effectiveness.